KLOTHO : THE MIRACLE PROTEIN THAT COULD REWRITE THE FATE OF AGING

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💪 Dear Wonderwomen and Supermen,

What if a single protein could extend our lifespan by 40%? That’s the bold bet of Klotho Neurosciences, a biotech company gaining attention for its technique targeting aging at its biological source.

Known for its work in neurology, it is now expanding its reach: muscles, bones, metabolism—nothing is left to chance.

Imagine a longer and healthier life, thanks to a gene therapy that restores a key aging factor: the klotho protein.

Curious? You’re in the right place. Let’s dive into this longevity revolution together.

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SPOTLIGHT

Klotho Neurosciences, initially focused on neurodegenerative diseases, is now expanding its mission: to slow down biological aging as a whole. By harnessing the properties of the klotho protein, this biotech is developing a new generation of therapies aimed at restoring vital age-related functions—from brain to muscles, bones to metabolism. The company claims its treatments could not only improve cognitive health but also enhance metabolic and physical resilience.

The Details :

• Klotho: A Foundational Discovery : Discovered in 1997, the klotho protein is named after a Greek goddess of fate. Overexpressing it in mice increased their lifespan by 30 to 40%. Since then, klotho has become a key biomarker of biological age, influencing metabolic, inflammatory, and repair pathways.

• Declining Levels With Age : Klotho levels naturally decrease over time, contributing to conditions such as cardiovascular disease, osteoporosis, sarcopenia, and neurodegeneration. Restoring its levels could reverse or slow these degenerative processes.

• KLTO-101 and KLTO-202: The First Weapons : Klotho Neuro’s flagship gene therapies target Alzheimer’s and ALS. A single injection stimulates endogenous klotho production, thereby supporting neuronal protection, cognitive function, and reducing oxidative stress.

• s-KL: The Secret Form With Systemic Effects : A recent study on aging mice showed that increasing the s-KL (secreted) form extended life by 20% and simultaneously improved overall health markers. Klotho Neuro now holds exclusive rights to this mechanism.

• Toward a Multi-Organ Approach to Aging : The biotech is no longer limited to the brain: it is exploring other longevity targets such as FOXO3 and anti-myostatin pathways. The goal: to preserve muscle strength, bone density, and metabolic balance.

Key Takeaway :

Klotho Neuro represents a new generation of biotech companies focused on extending healthy lifespan. By betting on a gene therapy that restores a key molecule of aging, the company could transform the way we approach age-related chronic diseases.
If its clinical trials confirm the promising results seen in animals, this could mark the beginning of a paradigm shift: moving from a reparative medicine to a preventive, regenerative, and holistic longevity medicine.

HYPE OR FACT ?

💭 Eating leafy greens has little impact on longevity

❌ HYPE

Epidemiological studies are clear: regular consumption of leafy greens like spinach, kale, or arugula is strongly correlated with reduced risk of cardiovascular disease, cancer, and cognitive decline. Rich in polyphenols, folate, fiber, magnesium, and vitamin K1, these vegetables act on inflammation, oxidative stress, and vascular health—three pillars of aging. A 2018 study published in Neurology shows that one daily serving is associated with a biologically younger brain by 11 years. Add them to your plate, without moderation.

LONGEVITY WISDOM

✨ Science Monday : A recent scientific discovery on longevity
🚀 Innovation Tuesday : Promising technological advancements extending life expectancy
🍏 Vitality Wednesday : Scientifically validated habits for a longer life
🧐 Myth-busting Thursday : Debunking common longevity myths
🎬 Inspiration Friday : An informative and inspiring longevity video

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