💪 Dear Wonderwomen and Supermen,
Did you know that GLP-1s — initially designed to treat diabetes — could become the key molecules of modern longevity?
This therapeutic shift is captivating researchers and investors alike. Their ability to reshape metabolism goes far beyond blood sugar control — we’re now talking about improving the quality of aging itself.
In the very first episode of the UNLOCKED podcast, two major figures in the field — Dr. Eric Verdin and Dr. Jens Juul Holst — reveal how these peptides could transform preventive medicine and health policy.
A must-listen for anyone passionate about performance, biotechnology… and the future.
SPOTLIGHT
The very first episode of the UNLOCKED podcast features a fascinating conversation between two major leaders in aging research : Dr. Eric Verdin, President of the Buck Institute, and Dr. Jens Juul Holst, pioneer of the discovery of GLP-1. Together, they retrace the spectacular rise of these peptides — evolving from blood sugar regulators to pillars of preventive metabolic medicine. The episode highlights a clear trend: the convergence of advances in biology, data science, and therapeutics not only to extend lifespan, but to significantly improve its quality. What if the future of longevity came down to a simple injection ?
The details :
GLP-1: from physiology to longevity : Dr. Holst explains how a fundamental discovery in digestive physiology became a major metabolic therapy. GLP-1s mimic a natural hormone that regulates appetite, blood sugar, and insulin. Their clinical effectiveness opens the door to a new preventive medicine against metabolic aging.
A therapeutic paradigm shift : According to Dr. Verdin, we are living through a historic transition: therapies are no longer only trying to cure, but to prevent. GLP-1s are part of this shift toward proactive medicine that targets the root causes of aging before disease develops.
Metabolic resilience and quality of life : GLP-1s go far beyond simple weight loss. They improve insulin sensitivity, reduce chronic inflammation, and promote a more stable metabolism — all key factors for healthier aging.
Economic and societal impact : The explosive commercial success of GLP-1s like Ozempic and Wegovy is reshaping healthcare economic models. Their massive adoption raises questions: how should public policies adapt to these new tools? Preventing rather than curing could become an economic necessity.
Toward a personalized longevity strategy : The episode also introduces the core mission of the UNLOCKED podcast: exploring personalized longevity strategies combining genetics, biology, and new molecules. GLP-1s may be the first pillar — but certainly not the last.
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Key Takeaway :
The debate around GLP-1s goes far beyond diabetes treatment or weight loss. These molecules represent a profound shift in how we approach health: targeting aging mechanisms upstream, before pathologies appear. While large-scale use raises ethical, economic, and medical challenges, their potential to improve metabolic resilience makes them a central tool in tomorrow’s medicine. In short, GLP-1s may be the first building blocks of a future where longevity means vitality — not simply more years lived.
HYPE OR FACT ?
💭 Taking NAD+ or NMN supplements is enough to slow aging
✅ FACT
Although supplements such as NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) can increase NAD+ levels — a molecule essential for cellular energy production — their effectiveness on human longevity is not yet proven. Rodent studies show promising effects, but human clinical trials remain limited. According to the National Institute on Aging, it is still too early to consider these molecules as validated anti-aging interventions. Lifestyle factors (sleep, fasting, exercise) remain today’s safest way to naturally support NAD+
LONGEVITY WISDOM
“Health is not everything, but without health, everything is nothing.”
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